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SYLOID® XDP 3150
SYLOID® XDP 3150 is a high-purity silica powder that provides superior adsorptive power of 1 to 1.5 times its weight in liquids while remaining a free-flowing, non-dusty material for pharmaceutical and nutraceutical applications. It helps to enhance the bioavailability and API loading in solid dosage forms and is especially useful for creating stable liquisolid formulations.
- Manufacturer: Grace
- Product Line: SYLOID® Silicas
- Product: SYLOID® Silica Excipients
- Industries: Pharmaceuticals
- Authorized Countries: Canada | United States
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Overview
SYLOID® XDP 3150 silica is an advanced porous carrier capable of absorbing up to 1 to 1.5 times its weight in liquids. It is designed with a high pore volume and large internal surface area for efficient liquid absorption in pharmaceutical and nutraceutical applications. ts high purity silica gel provides superior stability and excellent compatibility with active ingredients, while the narrow particle size distribution improves consistency and uniformity in formulations. As a synthetic amorphous silica in a high-purity white powder form, SYLOID® XDP 3150 is designed to transform liquids, particularly oily actives, and lipid-based systems, into stable, free-flowing solids, allowing for the convenient formulation of liquisolids, solid dispersions, semi-solids, and self-emulsifying drug delivery systems (SEDDS). Additionally, it ensures improved release of APIs from solid dosage forms without compromising quality.
Specifications
Appearance: Powder
Color: White
Loss on ignition (USP, 1000°F, 1 h): 8.5% max.
Loss on drying (USP, 145°C, 4 h): 5.0% max.
SiO₂ content (dry basis): 99.0% min
Sulfate (SO₄): 0.5% max
pH (USP, 5 % aqueous suspension): 4.0─8.0
pH (EP): 4.0─7.0
Average particle size malvern® Mastersizer®: 120─170 µm
Specific Surface Area (BET): 320 m²/g
Oil absorption (linseed oil): 300 g/100 g
Tapped bulk density: 275 g/l
Chlorides (Cl) dry basis, USP: 0.1 % max.
Mercury (Hg): 0.1 mg/kg max.
Iron Oxide (Fe₂O₃) dry basis: 0.03% max.
Sodium oxide (Na₂O) dry basis 0.15% max
Calcium Oxide (CaO): 0.14 % max.
Water Absorption (EP): yes
Substances soluble in HCl (EP): 10.0 mg max.
Arsenic (As): 0.5 mg/kg max.
Cadmium (Cd): 0.5 mg/kg max.
Lead (Pb): 1.0 mg/kg max.
Total aerobic plate count: 1000 cfu/g
CAS no. 7631-86-9
Primary Chemistry: Amorphous silicon dioxide
Features & Benefits
Amorphous silicon dioxide
Multifunctional excipient
Maximum load capacity
Excellent release and bioavailability
Free-flow additive
High purity
Improve manufacturing efficiency, dissolution, therapeutic effectiveness, and stability
Moisture protection
Reduces electrostatic charging
Improves flow properties
Moisture-assisted dry granulation
Excellent compatibility with actives
Oil absorption properties in lipid-based technologies
Prevents valve blockage in direct compression
Highly defined pore structures
Excellent porosity and particle size distribution
Enhanced moisture protection
Anti-sticking and anti-tacking
Absorbs up to 1.5 ml of liquid per gram
Matting agent
Anti-caking
Prevents clumping
Viscosity control
Problems Solved
Valve blockage in direct compression applications
Applications
APIs
Pharmacuetical products
Nutraceutical extracts
Film coatings
Sublingual and effervescent tablets
Liquisolid pharmaceuticals
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