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Neusilin® S1
Neusilin® S1 is an alkaline, synthetic magnesium aluminometasilicate with high water content. It has exceptional excipient properties including its use as a diluent, binder, and disintegration aid in oral solid-dosage form pharmaceuticals.
Neusilin® is a multifunctional excipient that can be used in both direct compression and wet granulation of solid dosage forms. Neusilin® improves the quality of tablets, powder, granules and capsules. Unlike other magnesium aluminum silicates, it does not develop gel with aqueous solutions.
Specifications
Appearance: White granules Degree of whiteness: > 95% Physical form: Amorphous True specific gravity: 2.0 Solubility: Practically insoluble in water and ethanol Composition on dried basis: Al2O3: 29.1% - 35.5% MgO: 11.4% - 14.0% SiO2: 29.2% - 35.6% Loss on drying (110°C, 7 hours): 13% - 20% Loose bulk density (g/mL): 0.30 - 0.37 Tapped bulk density (g/mL): 0.36 - 0.43 Specific surface area: 110 m²/g Average particle size: 112 μm Angle of repose: 30° Oil adsorbing capacity: 1.3 mL/g Water adsorbing capacity: 1.0 mL/g Acid consuming capacity: ≥ 210 mL/g pH (4% slurry): 8.5 - 10.0 EINECS number: 235-682-0 Chemical formula: Al2O3·MgO·1.7SiO2·xH2O
Features & Benefits
Superior compressibility; hard tablets can be made at low compression force Binds and improves hardness of other fillers and binders at low concentration Acts as a diluent in solid dosage forms Aids in tablet disintegration Very large specific surface area High oil and water adsorption capacity Heat stable Long shelf life (3 years) Meets all the requirements of the current USP/NF and JPC
Applications
Neusilin® S1 is typically used as a diluent in solid dosage forms as well as a binder, disintegration aid, and increases hardness in tablets.
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