AvailOm® and Biological Aging: Latest Omega-3 Research
How Omega-3s Influence Biological Aging
Aging is an inevitable process, but emerging research suggests that nutritional interventions can slow biological aging at the cellular level. A recent randomized controlled trial published in Nature Aging (DO-HEALTH - PMID: 39900648) provides compelling evidence that omega-3 supplementation, combined with vitamin D and structured exercise, can positively impact biological age as measured by DNA methylation clocks.
For formulators and product developers in functional foods, nutraceuticals, and personal care, these findings reinforce the growing demand for science-backed solutions that support longevity, cellular health, and overall vitality. AvailOm®, the highest-load omega-3 powder on the market, offers a convenient and highly bioavailable option to integrate these benefits into innovative formulations.
Key Findings from the DO-HEALTH Study
The DO-HEALTH trial followed 777 older adults (average age of 70 years) across five European countries over three years, evaluating the following effects:
Omega-3 fatty acids (1 g/day)
Vitamin D supplementation (2,000 IU/day)
Structured home-based exercise (targeting strength, balance, and flexibility)
Results: How Omega-3 Slows Biological Aging
The findings below align with broader research showing that omega-3 fatty acids play a crucial role in reducing inflammation, supporting cellular function, and promoting cardiovascular and metabolic health, all key factors in healthy aging.
Omega-3 supplementation alone slowed biological aging, as assessed by DNA methylation clocks.
Combining omega-3, vitamin D, and exercise had the strongest effect, reducing biological age by up to 3.8 months over three years (most significantly observed with the PhenoAge aging clock).
Exercise enhanced the effects of omega-3, reinforcing the role of holistic lifestyle interventions in promoting longevity.
Why AvailOm®? A High-Load, Bioavailable Omega-3 for Formulators
While omega-3s are well-known for their health benefits, formulators often face stability, absorption, and formulation challenges. AvailOm® overcomes these hurdles with a patented delivery system.
Superior Bioavailability: Up to five times higher absorption than standard fish oil
High-Load Powder Format: Delivers at least 50% omega-3 content, reducing formulation space constraints
Oxidation Stability: Highly resistant to oxidation, offering extended shelf life compared to traditional fish oils
Water Dispersibility: Ideal for functional foods, powders, and supplement applications
Algae-Based Option for Sustainable Omega-3s: AvailOm® is available in a plant-based formulation sourced from algae, providing sustainable EPA and DHA, the most bioactive forms of omega-3
EPA and DHA vs. ALA: Why the Source of Omega-3s Matters
Not all omega-3s offer the same health benefits. Many plant-based omega-3 sources, such as flaxseed and chia, provide ALA (alpha-linolenic acid), which the body must convert into EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). However, this conversion process is highly inefficient—less than 10% of ALA is successfully transformed into EPA and DHA.
In contrast, AvailOm® provides directly bioavailable EPA and DHA, which are scientifically linked to cardiovascular health, cognitive function, and reduced biological aging.
✓ Want to learn more about why EPA and DHA are superior to ALA? Click here to read our article.
Nutraceuticals &
Dietary Supplements
Healthy aging and longevity formulations
Cognitive health supplements
Cardiovascular and metabolic support
Functional Foods &
Beverages
Omega-3-fortified protein powders
Ready-to-mix nutritional drinks
Functional snacks and bars
Personal Care &
Beauty
Antiaging skin care formulations
Omega-3-enriched hair and nail supplements
What This Study Means for Formulators
The DO-HEALTH study highlights several important considerations when developing omega-3-based products for healthy aging.
Omega-3 supplementation benefits already healthy, active populations, but effects may be more pronounced in individuals with metabolic conditions.
Biological aging markers like DNA methylation clocks provide insight into long-term aging trajectories, but additional research is needed to confirm physiological impacts such as cardiovascular and cognitive function.
Combining omega-3s with complementary interventions—such as vitamin D and structured exercise—enhances their antiaging effects, opening opportunities for multifunctional product formulations.
Leverage the Science of Aging with AvailOm®
As the demand for evidence-backed longevity solutions grows, AvailOm® provides formulators with a high-load, stable, and highly absorbable omega-3 powder that seamlessly integrates into a wide range of nutraceutical and functional food applications.
✓ Want to explore formulation opportunities? Request a sample today.
✓ Need more technical data? Contact our team for detailed specifications.
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